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Noxa is a BH3-only member of the Bcl-2 family. Expression of Noxa gene involves direct activation of its promotor by p53. Increased expression of Noxa...
Notch proteins are transmembrane receptor that regluate cell fate decisions. Four Notch homologs have been identified in mammals namely Notch 1, Notch 2,...
NIK (NF-kB-inducing kinase) is a member of the MAP kinase kinase kinase family that binds TRAF2 and stimulates NF-kB activity. NIK was initially isolated...
IkB-alpha protein is a NF-kB inhibitory protein. It binds NF-kB and retains the complex in the cytoplasm, thereby preventing it from entering into nucleus...
NFkB is a heterodimer that consists of a 50kD DNA binding subunit (p50) and a 65kD transactivation subunit (p65/RelA). Both of these subunits exhibit...
NFkB was identified as a sequence specific transcriptional activator that binds to the intronic enhancer of kappa light chain gene in B lymphocytes. NFkB is...
Neurexins comprise a family of neuronal cell surface proteins present primarily in the brain. Neurexins are thought to serve as signaling receptors and may...
Nestin is a type IV intermediate filament protein expressed by neuroepithelial stem cells and which has been proposed to represent a marker for putative...
Nestin may play a role in the trafficking and distribution of IF proteins and potentially other cellular factors to daughter cells during progenitor cell...
Nectin is a cell-adhesion molecule that belongs to the immunoglobilin superfamily and is also known as the poliovirus receptor-related protein or PPR. Nectin...
NAIP (neuronal apoptosis inhibitor protein) is a member of the IAPs (inhibitor of apoptosis proteins) that function in cell death pathways to inhibit...
MAK10 protein regulates the proliferation of smooth muscle cells. The mammalian homolog of yeast MAK10, also known as EGAP, is one subunit of a novel...
Histone acetyltransferases (HATs) have been implicated in a number of cellular functions including gene regulation, DNA synthesis, and repair. Histone...
Histone acetyltransferases (HATs) have been implicated in a number of cellular functions including gene regulation, DNA synthesis, and repair. Histone...
Myeloperoxidase (MPO) is highly expressed in neutrophils and polymorphonuclear luekocytes. MPO is expressed as a dimer in regular neutrophils with a 140kD....
MyD88 was identified as an adapter molecule in the IL-1 signaling pathway. MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response...
MyD88 was identified as an adapter molecule in the IL-1 signaling pathway. MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response...
PID/MTA2, also termed MTA1-L1, is a novel molecule that has been found to be involved in p53 pathway. PID/MTA2 modulates the enzymatic activity of the...
Krs-1 protein exhibits stress-induced activity in response to staurosporine and okadaic acid. When the kinase-inactive mutant form of MST/Krs protein was...
DNA mismatch repair genes have been found to be associated with hereditary nonpolyposis colorectal cancer (HNPCC). Inherited mutations in the MSH2 were...
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