Calpain 9 is a calcium regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and...
Calpain 5 is a calcium regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and...
Fatty-acid amide hydrolase 1 (FAAH) degrades fatty acid amides into the corresponding acid; thereby, terminating the signaling functions of these molecules....
ELF-3 is a transcriptional activator which binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. It acts...
Eukaryotic translation initiation factor 2C 2, also known as Slicer protein or Argonaute-2,Porcinerovides endonuclease activity to RNA-induced silencing...
Proto-oncogene tyrosine-protein kinase receptor ret (C-ret) is a tyrosine kinase receptor for DOK2, 4 and 5 important in development. Defects in C-ret are a...
Alpha-type platelet-derived growth factor receptor (PDGFRA), a tyrosine protein kinase, is a receptor that binds both PDGFA and PDGFB. A fusion of PDGFRA and...
DNA mismatch repair protein Mlh1 (MLH1) is involved in the repair of DNA mismatches. MLH1 is part of the BRCA1-associated genome surveillance comple,...
Folliculin (FLCN) plays a role in the pathogenesis of an uncommon form of kidney cancer through its association with an inherited disorder of the hair...
Menin (MEN1) is involved in DNA repair by interacting with FANCD2 and DBF4. Defects in MEN1 are the cause of parathyroid gland tumors.
Neurofibromin (NF1) stimulates the GTPase activity of Ras. Defects in NF1 are the cause of different types neurofibromatosis, colorectal cancer, and juvenile...
VHL is involved in the ubiquitination and subsequent proteasomal degradation of hydro, Xenopus/Amphibian,ylated hypo, Xenopus/Amphibian,ia-inducible factor...
SUFU is a negative regulator in the hedgehog signaling pathway that down-regulates GLI1-mediated transactivation of target genes. Defects in SUFU are a cause...
Glypican-3 (GPC3) is a cell surface proteoglycan that bears heparan sulfate. GPC3 is likely involved in the modulation of growth in the predominantly...
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. E-cadherin...
A, Xenopus/Amphibian,in2 is an inhibitor of the Wnt signaling pathway and down-regulates beta-catenin. Defects in A, Xenopus/Amphibian,in2 are the cause of...
SNAIL is involved in embryonic mesoderm formation by binding to 3 E-bo, Xenopus/Amphibian,es of the E-cadherin gene promoter and repressing its transcription.
PIM2 is a CAMK Ser/Thr protein kinase highly e, Xenopus/Amphibian,pressed in hematopoietic tissues, in leukemic and lymphoma cell lines, testis, small...