Categories Molecular Biology
Cerebrospinal fluid (CSF) is secreted within the central nervous system (CNS) and fills in the ventricles, the subarachnoid space of the brain, and the...
Different fatty acids (FAs) vary greatly in the number of double bonds and the length of their carbon (C) chains. Very long-chain fatty acids (VLCFAs) are...
Fatty acids (FAs) are the main components of lipids, and the physical, chemical, and physiological properties of lipids mainly depend on their fatty acid...
To assess the appropriateness of candidate metabolites and to more comprehensively and intuitively display the relationships among samples and the...
Data completeness and accuracy is crucial for subsequent statistical and biological results. After verifying the experimental design and the accuracy of the...
Metabolic flux analysis (MFA) is a critical technique for examining the production and consumption rates of metabolites in biological systems. In systems...
Pain serves as the primary symptom across numerous pathological conditions. Obesity, significantly impacting the nervous system, is recognized as a systemic...
Diabetes is marked by hyperglycemia, resulting from defects in insulin secretion and action, which disturbs the metabolism of carbohydrates, fats, and...
Protein glycosylation not only influences the protein's spatial configuration, biological activity, transportation, and localization, but also plays a...
N-glycosylation is a post-translational modification involved in various physiological and pathological processes. The variability of glycosylation...
Small ubiquitin-like modifier (SUMO) is a post-translational modification of proteins that refers to the covalent attachment of a small ubiquitin-associated...
Protein oxidative modifications are generally induced by reactive oxygen species (ROS) such as superoxide anions, hydrogen peroxide, and hydroxyl radicals....
Methylation represents one of the most prevalent post-translational modifications, chiefly affecting transcription factors and histones, though it also...
Protein deamidation involves the conversion of amide groups (-CONH2) in amino acids like glutamic acid and aspartic acid into their corresponding acids,...
Unlike N-glycans, O-glycans are smaller, highly diversified branched carbohydrate molecules that can attach to various protein structures. This...
Glycosylation analysis is one of the most challenging types of post-translational modification (PTM) analysis. Glycosylation modifications typically occur at...
O-glycosylation typically occurs in secreted proteins and membrane-bound proteins, taking place within the Golgi apparatus. O-glycans are linked to proteins...
Glycosylation primarily refers to the enzymatic process of linking polysaccharides to proteins, lipids, or other organic molecules, and is the most common...
Glycosidic bonds rarely affect the function of glycoproteins, thus they are usually not necessary to determine. However, the glycan structure of...
Glycosylation modifications increase the complexity of protein molecular structure and the diversity of functions, not only affecting protein folding,...
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