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ACTR1A (Alpha-centractin, Centractin, ARP1, Actin-RPV, Centrosome-associated Actin Homolog, CTRN1)

ACTR1A (Alpha-centractin, Centractin, ARP1, Actin-RPV, Centrosome-associated Actin Homolog, CTRN1)

Cat no: A0857-40D

Supplier: United States Biological
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The actin-related protein ACTR1A, a member of the superfamily of actin-related proteins, is the major subunit of the dynactin complex, a key component of the cytoplasmic dynein motor machinery. The major components of the dynactin complex, consisting of at least ten polypeptides, include ACTR1A. ACTR1A, the most abundant subunit in the dynactin complex, is most similar to conventional actin (>50% aa identity). The dynactin complex has been shown to localize to multiple structures within the cell, including membrane organelles, the centrosome, spindle poles, and spindle pole microtubules during mitosis and prometaphase kinetochores. It regulates dyneinmediated vesicle movement on microtubules as well as spindle assembly and cell division. ACTR1A overexpression in cells results in aberrant spindle morphologies and cell cycle delay at prometaphase, suggesting a possible function of ACTR1A/dynactin complex in progression through the prometaphase of mitosis. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-3ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human kidney lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: A0857-40D
Reactivities: Human
Hosts: Goat
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Lees-Miller JP, Helfman DM, Schroer TA.A vertebrate actin-related protein is a component of a multisubunit complex involved in microtubule-based vesicle motility.Nature. 1992 Sep 17;359(6392):244-6. PMID: 1528266.
Additional info: Recognizes human ACTR1A. Species sequence homology: mouse and rat.

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