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ADP Ribosylation Factor Interacting Protein 2 (ARFIP2, Arfaptin 2, Partner of RAC1, POR1)

Cat no: A0902-51

ADP Ribosylation Factor Interacting Protein 2 (ARFIP2, Arfaptin 2, Partner of RAC1, POR1)

Arfaptin 2, or ADP-ribosylation factor interacting protein 2, is a Rac1 binding protein necessary for Rac-mediated actin polymerization and the subsequent formation of membrane ruffles and lamellipodia.1 Arfaptin-2 has been shown to be involved in interactions between the Rac and ARF signaling pathways.2 Arfaptin 2 also regulates the aggregation of mutant Huntingtin protein by possibly impairing proteasome function. Expression of Arfaptin 2 was shown to be increased at sites of neurodegeneration. Mutant Huntingtin protein is characteristic of Huntington

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SPECIFICATIONS

Catalog Number

A0902-51

Size

50ug

Applications

ELISA, WB

Hosts

Ch/Bird

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgY

References

1. Joneson T, et al. Science 274: 1374-1376, 1996. 2. Shin OH and Exton JH. Biochem Biophys Res Comm 285:1267-1273, 2001. 3. Peters PJ, et al. Nat Cell Biol 4(3):240-245, 2002.

Additional Info

Recognizes human ADP Ribosylation Factor Interacting Protein 2. Species Crossreactivity: Mouse and rat.

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