Adrenergic alpha 1A Receptor (Alpha-1A Adrenergic Receptor, Alpha-1A Adrenoreceptor, Alpha-1A Adrenoceptor, ADRA1A, ALPHA1AAR, Alpha-1C Adrenergic Receptor, Alpha-adrenergic Receptor 1c, ADRA1C, ADRA1L1)

The alpha 1c- Adrenergic Receptor, also known as alpha 1a-adrenoceptor, is activated by epinephrine and norepinephrine. This receptor mediates calcium release upon ligand binding. The alpha 1-c adrenoceptor is one of three subtypes of alpha 1-adrenergic receptor (alpha 1 c/a, alpha 1b, and alpha 1d). The alpha 1c receptor couples to phospholipase C via a GTP-binding protein insensitive to pertussis toxin. Three isoforms are generated by alternative splicing. However, the corresponding isoforms of the protein have similar ligand-binding properties, effector coupling, and tissue distribution. Expression of this receptor has been reported in prostate, liver, kidney, heart, brain, spinal cord, bladder, and various blood vessels. ESTs have been isolated from liver and testis libraries. Caution: The name ADRA1A has been used to describe both the alpha 1c adrenoceptor (Human chromosome 20) and the alpha 1d adrenoceptor (Human chromosome 8), and the alpha 1c adrenoceptor is also known as alpha 1a adrenoceptor.\n\nApplications:\nSuitable for use in Immunofluorescence and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunofluorescence/ICC: assay dependent dilution\nImmunohistochemistry (paraffin): 6ug/ml\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nHuman brain\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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