Bmi-1 (BUP, RNF51, MGC12685, BUP, Polycomb group RING finger protein 4)

Description:\nThe transcriptional repressor BMI-1 was first identified as a proto-oncogene frequently activated by Moloney murine leukemia proviral insertions in mice and cooperating with c-myc in the generation of mouse lymphomas (1). BMI-1 is involved in segment specification, cell growth and maintenance, transcriptional regulation, and chromatin modification. A major target of BMI-1 is the ink4a locus which encodes tumor suppressor proteins p16 and p19Arf, \nwhich are important in tumor progression and thought to be critical in cell proliferation and senescence (2). Recent studies have also shown that BMI-1 is required for the maintenance of adult normal and leukemic stem cells (3), suggesting that BMI-1 could an attractive therapeutic \ntarget for stem cell proliferation and renewal as well as for anti-cancer strategies. \n\nApplications:\nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 0.5-1ug

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SPECIFICATIONS

Catalog Number

B2185-03

Size

100ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Alkema MJ, et al. Hum. Mol. Genet. 1993; 2:1597-603. 2. Jacobs JJ, et al. Nature 1999; 397:164- 8. 3. Lessard J and Sauvageau G. Nature 2003; 255-60. WD0206)

Additional Info

Recognizes human BMI-1. Species Crossreactivity: mouse and rat.