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Caspase 2, NT (casp2)

Caspase 2, NT (casp2)

Cat no: C2086-79A

Supplier: United States Biological
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Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase- 1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1b and IL-18. Although phylogenetically similar to this subfamily, caspase-2 is thought to be involved in stress-induced apoptosis. Caspase-2 has two major isoforms; over-expression on the long form results in apoptosis while that of the short form suppresses cell death. Zebrafish has been used as a model for the research of caspase-2 functions. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:5000-1:20,000 Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Control Peptide: C2086-79E Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2086-79A
Reactivities: Zebrafish/Fish
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 250ul
Form: Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Martinon, F. et al. Cell (2004; 117, 561. 2. Zhivotovsky, B. et al. Science 1995; 267, 2000. 3. Gracie, JA. et al. J. Leukoc. Biol. 2003; 73, 213. 4. Lassus, P. et al. Science 2002; 10, 1352. 5. Wang, L. et al. Cell 1994; 739. 6. Sidi S, et al. Cell. 2008; 30; 133(5): 864-77. 7. Eimon PM, et al. Cell Death Differ. 2006; 13(10): 1619-30. 8. Inohara N, Nu
Additional info: Recognizes zebrafish Caspase-2.

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