Home  >  Products  >  Catenin, delta 1, phosphorylated (Tyr228) (CTNND1, Cadherin-Associated Protein delta 1, Cadherin-associated Src Substrate, CAS, p120 Catenin, p120(ctn), p120(cas), KIAA0384)
Catenin, delta 1, phosphorylated (Tyr228) (CTNND1, Cadherin-Associated Protein delta 1, Cadherin-associated Src Substrate, CAS, p120 Catenin, p120(ctn), p120(cas), KIAA0384)

Catenin, delta 1, phosphorylated (Tyr228) (CTNND1, Cadherin-Associated Protein delta 1, Cadherin-associated Src Substrate, CAS, p120 Catenin, p120(ctn), p120(cas), KIAA0384)

Cat no: C2069-54M

Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Read More on Supplier Website
Catenin d-1 (p120 catenin) has an amino- terminal coiled-coil domain followed by a regulatory domain containing multiple phosphorylation sites and a central Armadillo repeat domain of ten, linked 42 amino-acid repeats. The carboxy-terminal tail has no known function (1). Catenin d-1 fulfills critical roles in the regulation of cell-cell adhesion as it regulates E-cadherin turnover at the cell surface to determine the level of E-cadherin available for cell-cell adhesion (2). Catenin d-1 has both positive and negative effects on cadherin-mediated adhesion (3). Actin dynamics are also regulated by catenin d-1, which modulates RhoA, Rac and cdc42 proteins (1). Analogous to b-catenin, catenin d-1 translocates to the nucleus although its role at this location is unclear. Many studies show that catenin d-1 is expressed irregularly or is absent in various types of tumor cells, suggesting that catenin d-1 may func- tion as a tumor suppressor (4). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2069-54M
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100ug/ml BSA and 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by peptide affinity chromatography.
References: 1. Reynolds, A.B. and Roczniak-Ferguson, A. (2004) Oncogene 23:7947
Additional info: Detects endogenous levels of catenin d-1 protein only when phosphorylated at Tyr228. The antibody might cross react with another overexpressed phospho-tyrosine protein.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave