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Catenin-(gamma) (731) pAb

Catenin-(gamma) (731) pAb

Cat no: BS1042

Supplier: Bioworld Technology, Inc.
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The catenins, (alpha), (beta) and (gamma), are proteins which bind to the highly conserved,intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherincomplexes play an important role mediating cellular adhesion. (alpha)-catenin was initially described as an E-cadherin associated protein, and since has been shown to associate with other members of the cadherin family, such as N-cadherin and P-cadherin. (beta)-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. (beta)-catenin has also been found in complexes with the tumor suppressor protein APC. (gamma)-catenin, also known as plakoglobin, binds with (alpha)-catenin and N-cadherin. It has been shown that the transmembrane phosphatase PTPmicro associates with catenin/cadherin complexes and may regulate complex signaling.
Catalogue number: BS1042
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunofluorescence, Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P14923
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 700-750 of Human Catenin-(gamma).
Species: Catenin-(gamma) (731) pAb detects endogenous levels of Catenin-(gamma) protein.
Molecular weight: ~ 82 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Junction plakoglobin; Catenin gamma; Desmoplakin-3; CTNNG; DP3, JUP
Additional info: For research use only, not for use in diagnostic procedure.

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