Home  >  Products  >  Catenin, gamma (Catenin (Cadherin-associated Protein) gamma (80kD), CTNNG, ARVD12, Desmoplakin 3, Desmoplakin-3, DP3, Desmoplakin III, Desmoplakin-III, DPIII, Gamma Catenin, Junction Plakoglobin, JUP, PDGB, PKGB)
Catenin, gamma (Catenin (Cadherin-associated Protein) gamma (80kD), CTNNG, ARVD12, Desmoplakin 3, Desmoplakin-3, DP3, Desmoplakin III, Desmoplakin-III, DPIII, Gamma Catenin, Junction Plakoglobin, JUP, PDGB, PKGB)

Catenin, gamma (Catenin (Cadherin-associated Protein) gamma (80kD), CTNNG, ARVD12, Desmoplakin 3, Desmoplakin-3, DP3, Desmoplakin III, Desmoplakin-III, DPIII, Gamma Catenin, Junction Plakoglobin, JUP, PDGB, PKGB)

Cat no: C2069-57A

Supplier: United States Biological
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Plakoglobin, also known as gamma-catenin belongs together with alpha- and beta catenin to the catenin family. Catenins mediates cell-cell adhesion by interaction with cadherins. Plakoglobin is found in desmosomes and adherens junctions. Plakoglobin is highly homologous to beta-catenin although its function differs from that of beta-catenin. Whereas beta-catenin has been found in potentiating hyperproliferation and tumor formation, plakoglobin can suppress tumorigenicity. Overexpression of plakoglobin has been shown to suppress cell proliferation and cell tumorigenicity in animals. Furthermore reduced plakoglobin expression has been found in tumor tissues and metastatic lesions of renal cells, esophageal carcinomas and in skin carcinomas. Applications: Suitable for use in Western Blot, Immunoprecipitation and Immunofluorescence. Other applications not tested. Recommended Dilution: Western Blot: 1:10 Immunoflourescence: 1:10; fix cells with paraformaldehyde Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2069-57A
Reactivities: Human, Rat
Hosts: Mouse
Applications: Immunofluorescence, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.1% BSA.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
Alternative names: OTTHUMP00000164735
References: 1. Sacco, P et al; Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin. J Biol Chem 1995, 34: 20201. 2. Wahl, J et al; Plakoglobin domains that define its association with the desmosomal cadherins and the classical cadherins: identification of unique and shared domains. J Cell Sci 1996, 109: 1143. 3. Lewis, J et al; Cross-talk between adherens junctions and desmosomes depends on plakoglobin. J Cell Biol 1997, 136: 919. 4. Amitay, R et al; Reduced expression of plakoglobin correlates with adverse outcome in patients with neuroblastoma. Am J Pathol 2001, 159: 43.
Additional info: Recognizes human gamma catenin. Species Crossreactivity: rat, weakly with mouse.

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