CD19

CD19 is a monomeric transmembrane glycoprotein expressed at relatively constant levels throughout B cell development from early pro-B/pre-B cells (i.e., B220+/CD43+/HSA+) through fully differentiated B cell stages.1-7 Terminally differentiated plasma cells do not express CD19.1 In humans, the CD19 molecule on the surface of mature B cells associates with CD21 (CR-2) and CD81 (TAPA-1), and this multimolecular complex synergizes with surface immunoglobulin to provide signal transduction and promote cellular activation.3, 4 All splenic and peritoneal IgM+ cells of both B-1 and B-2 lineages are CD19+, with B-1 cells expressing higher levels of CD19 than B-2 cells in these sites.1, 7 Recent studies with CD19-deficient mice have suggested that this molecule may not be required for normal generation and maturation of B cells in the bone marrow.7\n\nApplications:\n

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SPECIFICATIONS

Catalog Number

C2269-73

Size

500ug

Applications

FC, IP

Hosts

Mouse

Reactivities

Mouse

Form

Supplied as a liquid in 100mM borate buffered saline, pH 8.0. No preservatives or amine-containing buffer salts added.

P Type

Mab

Purity

Purified

Isotype

IgA,k

References

1. Sato, S., N. Ono, D.A. Steeber, D.S. Pisetsky, and T.F. Tedder. 1996. J. Immunol. 157:4371-4378.\n2. Krop, I., A.R. Fougerolles, R.R. Hardy, M. Allison, M.S. Schlissel, and D.T. Fearon. 1996. Eur. J. Immunol. 26:238.\n3. Krop, I., A.L. Shaffer, D.T. Fearon, and M.S. Schlissel. 1996. J. Immunol. 157:48.\n4. Fearon, D.T. 1993. Curr. Opin. in Immunol. 5:341.\n5. Tedder, T.F., L.-J. Zhou, and P. Engel. 1994. Immunol. Today 15:437.\n6. Rickert, R.C., K. Rajewsky, and J. Roes. 1995. Nature 376:352.\n7. Engel, P., L.-J. Zhou, D.C. Ord, S. Sato, B. Koller, and T.F. Tedder. 1995. Immunity 3:39.\n8. Rolink, A., E. ten Boekel, F. Melchers, D.T. Fearon, I. Krop, and J. Andersson. 1996. J. Exp. Med. 183:187.

Additional Info

Recognizes CD19 B cell differentiation antigen, Mr 95kD.