CD1a (T-cell Surface Glycoprotein CD1a, T-cell Surface Antigen T6/Leu-6, hTa1 Thymocyte Antigen, CD1A)

CD1a, a 45kD cell-surface glycoprotein, is a novel member of MHC class I family. It is associated with beta2-microglobulin and is predominantly expressed in thymocytes and dendritic cells. It belongs to the Group I CD1 isoforms and is involved in the presentation of self and foreign lipid antigens to T-cells. CD1a is often used as a marker for dendritic cells. Pathophysiological role of CD1a has been associated with autoimmune disorders and malignancies.\n\nApplications:\nSuitable for use in Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:: \nImmunohistochemistry (formalin fixed paraffin embedded): 1:25-1:50\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nTonsil\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

C2252-01Q

Size

500ul

Applications

IHC

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid, 0.05% sodium azide.

P Type

Mab

Purity

Supernatant

Isotype

IgG1

References

1. Aractingi et al. J Clin Pathol 50: 305, 1997. 2. Bobryshev et al. Pathol Res Pract 192: 462, 1996. 3. Mazal et al. Clin Neuropathol 15: 87, 1996. 4. Roura-Mir et.al J Immunol 174: 3773-3780 (2005) 5. Coventry et.al Trends in Immunology 25 (5) 242-248 (May 1, 2004).

Additional Info

Recognizes human CD1a.