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CD1b (T-cell Surface Glycoprotein CD1b, CD1b)

CD1b (T-cell Surface Glycoprotein CD1b, CD1b)

Cat no: C2252-02Q

Supplier: United States Biological
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CD1b is a 43kD member of the immunoglobulin superfamily also known as R1. It is a type I membrane glycoprotein with structural similarities to MHC class I and is non-covalently associated with B2-microglobulin. In humans, CD1 family consists of group I proteins (CD1a, CD1b, CD1c), group II (CD1d), and group III (CD1e). CD1b plays a role in non-peptide glycolipid antigen presentation to CD1-restricted T cells. It is expressed on cortical double positive and single positive thymocytes, Langerhans cells, and dendritic cells. In addition to antigen presentation, CD1b has been implicated in thymic T cell development. Applications: Suitable for use in Immunofluorescence, Flow Cytometry and Immunoprecipitation. Other applications not tested. Recommended Dilution: Flow Cytometry: (same/less than)0.5ug/10e6 cells in 100ul Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2252-02Q
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunofluorescence, Immunoprecipitation
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Hayes, S.M., et al. 2001. J. Immunol. 166:403. (IF) 2. Martin, L.H., et al. 1987. P. Natl. Acad. Sci. USA 84:918993. (IF) 3. Porcelli, S., et al. 1992. Nature 360:5937. 4. Giuliani, A., et al. 2001. Infect. Immun. 69:746170.
Additional info: Recognizes human CD1b.

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