CD1c (Cluster of differentiation antigen 1c) is a 43kD member of the CD1 family of molecules. It is expressed by thymocytes, dendritic cells, and B cells, and exists as part of a noncovalent complex with 12kD b2-microglobulin. It is found in the plasma membrane and early endosomes (but not lysosomes), and is presumed to present glycolipids and acylated peptides to T cells. Mature human CD1c is a 316aa(aa) type I transmembrane glycoprotein. It contains a 285 aa extracellular domain (ECD; aa18-302) plus a 10 aa cytoplasmic tail. The ECD shows one Ig-like domain (aa203-296) that associates with b2-microglobulin, and a Tyr-Gln-Asp-Ile internalization motif in the cytoplasmic tail. There are three potential splice variants. One shows a Trp substitution for aa 327-333, a second shows an eight aa substitution for aa 298-333, and a third shows a 50 aa substitution for aa 297-333. There appears to be no direct mouse counterpart to human CD1c.
Applications:
Suitable for use in Flow Cytometry. Other applications not tested.
Recommended Dilutions:
Optimal dilutions to be determined by the researcher
Storage and Stability:
May be stored at 4 degrees C before opening. DO NOT FREEZE! Stable at 4 degrees C as an undiluted liquid. Dilute only prior to immediate use. Stable for at least 12 months at 4 degrees C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.
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