CD24 (GPI-linked surface Mucin, Nectadrin) (Azide Free)

CD24 is expressed in B cells until their terminal differentiation into plasma cells.1 It has been used widely as a marker to fractionate different B-lineage differentiation stages.10 CD24 has been found on a variety of other hematopoietic and neural cell types, and is now classified as a costimulatory molecule.2-4 The CD24/HSA molecule is composed mostly of carbohydrate, with a protein core of only 31-35 amino acids in the human and 27 amino acids in the mouse.1, 3 The molecular mass is variable, ranging from 38-70kD.3 CD24 is now included in the large group of phosphatidylinositol-anchored membrane proteins.1-4 Studies with purified CD24 applied to latex beads have demonstrated a self-binding property, suggesting that the molecule is capable of promoting homotypic aggregation, binding and cell adhesion.3 This is supported by earlier observations of the blockade of B cell lymphoblast aggregation with anti-CD24 monoclonal antibody.6 Recent studies of murine CD24 have assigned a role for CD24/HSA as a\nligand for P-selectin, a calcium-dependent lectin.7\n\nApplications:\n

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SPECIFICATIONS

Catalog Number

C2275-11F

Size

500ug

Applications

FC, IP

Hosts

Rat

Reactivities

Mouse

Form

Supplied as a liquid in PBS. No preservative added.

P Type

Mab

Purity

Purified

Isotype

IgG2c,k

References

1. Kay, R., P. M. Rosten and R. K. Humphries. 1991. J. Immunol. 147:1412-1416.\n2. Fischer, G. F., O. Majdic, S. Gadd, and W. Knapp. 1990. J. Immunol. 144:638.\n3. Hubbe, M. and P. Altevogt. 1994. Eur. J. Immunol. 1994. 24:731.\n4. Liu, Y., B. Jones, W. Brady, J. C. A. Janeway, and P. S. Linsley. 1992. Eur. J. Immunol. 22:2855.\n5. Shields, J. G., S. H. Smith and R. E. Callard. 1987. In Leukocyte Typing III. A. J. McMichael, et. al., eds., Oxford University Press, Oxford. P. 488.\n6. Kadmon, G., M. Eckert, M. Sammar, M. Schachner, and P. Altevogt. 1992. J. Cell Biol. 118:1245.\n7. Aigner, S., M. Ruppert, M. Hubbe, M. Sammar, Z. Sthoeger, E. C. Butcher, D. Vestweber, and P. Altevogt. 1995. International Immunology 7:1557.\n8. Ledbetter, J. A., and L. A. Herzenberg. 1979. Immunol. Rev. 47: 63.\n9. Kariv, I., R. R. Hardy and K. Hayakawa. 1994. J. Exp. Med. 180:2419.\n10. Hardy, R. R., C. E. Carmack, S. A. Shinton, J. D. Kemp, and K. Hayakawa. 1991. J. Exp. Med 173:1213.

Additional Info

Recognizes mouse CD24.