CD27 (CD27 Antigen, CD27L Receptor, T-cell Activation Antigen CD27, T14, Tumor Necrosis Factor Receptor Superfamily Member 7, TNFRSF7)

CD27 is a 50-55 kD type I membrane protein also known as S152 and T14. It is a lymphocyte-specific member of the TNF-receptor superfamily. CD27 is expressed on medullary thymocytes, virtually all mature T cells, some B cells and NK cells. CD27 binds to CD70, and plays an important role in costimulation of T cell activation and regulation of B cell differentiation and proliferation. The cytoplasmic domains of CD27 have also been shown to interact with TRAF2 and TRAF5 to elicit NF-kB and SAPK/JNK activation.\n\nApplications:\nSuitable for use in Flow Cytometry. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

C2379-10L

Size

100ug

Applications

FC

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

P Type

Mab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG1,k

References

1. Knapp, W., et al. Eds. 1989. Leucocyte Typing IV. Oxford University Press. New York. 2. Hintzen, R., et al. 1994. Immunol. Today 15:307. 3. Agematsu, K., et al. 1995. J. Immunol. 154:3627.

Additional Info

Recognizes human CD27. Species Crossreactivity: baboon, cynomolgus, rhesus.