CD28 (CD28 Antigen, CD28 Molecule, MGC138290, T cell Antigen CD28, T cell Specific Surface Glycoprotein, T cell Specific Surface Glycoprotein CD28, Tp44) (Azide Free)

CD28 is a type I disulfide-linked homodimer that is constitutively expressed on most thymocytes, at low density on nearly all CD4+ and CD8+ peripheral T lymphocytes, and at very low levels on NK cells. Its expression is upregulated upon T-cell activation. 1-4 CD28 is a ligand for CD80/B7-1 and CD86/B7-2 on B cells and other antigen presenting cells, and plays an important role in the interaction between T cells and B cells. CD28 is a co-stimulatory receptor involved in many, but not all, T-cell independent immune responses.5-8\n\nApplications:\n

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

C2380-18AX

Size

500ug

Applications

FC, IP

Reactivities

Mouse

Form

Supplied as a liquid in PBS. No preservative added.

P Type

Mab

Purity

Purified

Isotype

IgG,l

References

1. Gross, J. A., E. Callas, and J. P. Allison. 1992. J. Immunol. 149:380.\n2. Giese, T., J. P. Allison, and W. F. Davidson. 1993. J. Immunol. 151:597.\n3. Clements, J. L., G. Winslow, C. Donahue, S. M. Cooper, J. P. Allison, and R. C. Budd. 1993. Int. Immunol. 5:1451.\n4. Nandi, D., J. A. Gross, and J. P. Allison. 1994. J. Immunol. 152:3361.\n5. June, C.H., J.A. Bluestone, L.M. Nadler, and C.B. Thompson. 1992. Immunol. Today 15:321.\n6. Gelfanov, V., Y. G. Lai, V. Gelfanova, J. Y. Dong, J. P. Su, and N. S. Liao. 1995. J. Immunol. 155:76.\n7. Harding, F. A., J. G. McArthur, J. A. Gross, D. H. Raulet, and J. P. Allison. 1992. Nature 356:607.\n8. Bluestone, J.A. 1995. Immunity 2:555.

Additional Info

Recognizes CD28 costimulatory receptor, Mr 40kD.