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CD32/CD16 (Fc gamma Receptor II/III, FcRII/III, Monocyte Activation Antigen gp40)

Cat no: C2384-13

CD32/CD16 (Fc gamma Receptor II/III, FcRII/III, Monocyte Activation Antigen gp40)

The CD32 molecule (FcgammaRII) represents a 40kD low af?nity receptor for IgG with af?nity for complexed or aggregated IgG. This class of Fc gamma Receptor consists of at least six isoforms originating from three different genes (Fc gamma RIIA, B and C) and alternative splicing. These receptors mediate a host of functions including endocytosis, stimulation of secretion, cytotoxic responses and immunomodulation. Fc gamma RII is expressed on every Fc gamma R-bearing cell with the exception of natural killer cells. Expression of the Fc gamma RIIA gene is found on monocytes, neutrophils and platelets and at a low level on B lymphocytes. The Fc gamma RIIB comprises three isoforms: Fc gamma RIIb1, IIb2 and IIb3. The Fc gamma RIIb1 and IIb2 transcripts were found to be expressed on B lymphocytes. \n\nApplications: \nSuitable for use in Flow Cytometry. Other applications not tested.\n\nRecommended Dilutions:\nFlow Cytometry: 1ug to stain 1x10e6 cells\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

C2384-13

Size

500ug

Applications

FC

Hosts

Rat

Reactivities

Mouse

Form

Supplied as a liquid in PBS, pH 7.4, 1% BSA, 0.09% sodium azide

P Type

Mab

Purity

Purified by Protein G affinity chromatography

Isotype

IgG1

References

1. Titas, J.A. et al. (1982) J. Immunol. 133:556. 2. Rodewald, H. et al. (1992) Cell 69:139

Additional Info

Recognizes mouse Fc Receptor II and Fc Receptor III

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SUPPLIER INFO

Applications

ELISA

Reactivities

Hum

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Applications

IF

Hosts

Mouse

More info

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, IHC, WB

Hosts

Mouse

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Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info

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