CD36 (gpIIIb, gpIV, Thrombospondin Receptor)

CD36 (also known as platelet glycoprotein IV, OKM5-antigen, or platelet glycoprotein IIIb) acts as a receptor for thrombospondin (TSP), collagen, falciparum malaria parasitized erythrocytes, and sickle erythrocytes. It also functions as a scavenger receptor, mediating macrophage uptake of oxidized low density lipoprotein (LDL), and apoptotic polymorphonuclear leukocytes (PMN). CD36 plays a role in platelet aggregation, macrophage foam cell development, inflammation, and the tissue ischaemia observed in sickle cell disease and cerebral malaria.\n\nApplications: \nSuitable for use in Function Blocking, Flow Cytometry, Immunofluorescence, and Immunohistochemistry. Not suitable for use in Western Blot. Other applications have not been tested.\n\nRecommended Dilution:\nFunction Blocking: Order C2388-15X.\nImmunohistochemistry: Frozen\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nTonsil\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

C2388-15

Size

500ul

Applications

FC, IF, IHC

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in 10mM PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide. Also available without BSA and azide, See C2388-15X.

P Type

Mab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG2a,k

References

1. Kishimoto, T., et al., eds. Leukocyte Typing VI, p636-643 and p1136-1137 (1997), Garland Publishing, Inc, New York and London. 2. Greenwalt, D.E., Ikeda, H.,Tandon, N.N., Jamieson, G.A.: Membrane glycoprotein CD36: a review of its roles in adherence, signal transduction, and transfusion medicine. Blood 80: 1105 (1992). 3. Savill, J., et al.: Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis. J. Clin. Invest. 90(4): 1513-1522 (1992). 4. Stomski, F.C., et. al., Experimental Cell Research 198(1): 85-92 (1992). 5. Biggs, B.A., et al., Journal of Experimental Medicine 171(6): 1883-1892 (1990).

Additional Info

Recognizes human CD36 (MW: 88kD). Blocks adhesion of P. falciparum parasitized red blood cells to CD36. Strongly inhibits collagen-induced platelet aggregation.