CD56 (NCAM-1, Neural Cell Adhesion Molecule)

CD56, an isoform of the neural cell adhesion molecule (NCAM), is a 220kD heavily glycosylated type I transmembrane protein. On human hematopoietic cells, its expression is restricted to NK cells and a subpopulation of T lymphocytes (known as large granular lymphocytes) which demonstrate natural killer activity. While it is clear that NCAM plays a role in homotypic adhesion of neuronal cells, the significance of CD56 expression on NK cells is not clear and remains controversial.\n\nApplications:\nSuitable for use in Flow Cytometry. Other applications have not been tested. \n\nRecommended Dilutions:\nFlow Cytometry: (same/less than)1ug/10e6 cells.\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

C2410-60A

Size

100ug

Applications

FC

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in 100mM borate buffered saline, pH 8.2 before the addition of glycerol to 40%. No preservatives or amine-containing buffer salts added.

P Type

Mab

Purity

Purified

Isotype

IgG2a

References

1. Schlossman, S., L. Bloumsell, W. Gilks, J.M. Harlan, C. Kishimoto, J. Ritz, S. Shaw, R. Silverstein, T. Springer, T.F. Tedder, and R.F. Todd, eds. 1995. Leukocyte Typing V: White Cell Differentiation Antigens, Oxford University Press, Oxford. 2. Barclay, A.N., M.H. Brown, S.K.A. Law, A.J. McKnight, M.G. Tomlinson, and P.A. van der Merwe, eds. 1997. The Leukocyte Antigens Facts Book, 2nd Edition, CD56 Section, Academic Press, New York, p. 284. 3. Rabinowitz, J.E., U. Rutishauser, and T. Magnuson. (1996) Proc. Natl. Acad. Sci. USA 93:6421. 4. Muller, D., C. Wang, G. Skibo, N. Toni, H. Cremer, V. Calaora, G. Rougon, and J.Z. Kiss. (1996) Neuron 17:413.

Additional Info

Recognizes human CD56/NCAM.