CD62L (gp90 MEL, hLHRc, L Selectin, L-Selectin, LECAM-1, Lymph Node Homing Receptor, LNHR, Lymphocyte Adhesion Molecule 1, LYAM1, PLNHR, Selectin L, SELL, TQ1)

CD62L, also known as L-selectin, is a type I transmembrane glycoprotein with lectin-like and Epidermal Growth Factor-like domains.1, 2 It binds to sialylated oligosaccharide determinants on high endothelial venules (HEV) in peripheral lymph nodes.1, 2 In the mouse, CD62L is expressed on most thymocytes and on peripheral leukocytes, including B and T lymphocytes, neutrophils, monocytes and eosinophils.3-7 This member of the selectin family of cell adhesion molecules appears to be required for lymphocyte homing to peripheral lymph nodes and for leukocyte extravasation at sites of inflammation.1, 2, 7-9 Expression of CD62L on lymphocytes and neutrophils is rapidly down-regulated upon cell activation and the level of CD62L expression, along with other markers, distinguishes naive T cells from effector/memory T cells.10-13 The monoclonal antibody blocks in vitro binding of lymphocytes to peripheral lymph node HEV and inhibits in vivo lymphocyte extravasation into peripheral lymph nodes and the late stages of leukocyte rolling.1, 2, 7-9\n\nApplications:\n

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SPECIFICATIONS

Catalog Number

C2415-31A

Size

500ug

Applications

FC, IHC, IP

Hosts

Rat

Reactivities

Mouse

Form

Supplied as a liquid in 100mM borate buffered saline, pH 8.0. No preservatives or amine-containing buffer salts added.

P Type

Mab

Purity

Purified

Isotype

IgG2a,k

References

1. Gallatin, W.M., I.L. Weissman, and E.C. Butcher. 1983. Nature 304:30.\n2. Siegelman, M.H., I.C. Cheng,, I.L. Weissman, and E.K. Wakeland. 1990. Cell 61:611.\n3. Reichert, R.A., I.L. Weissman, and E.C. Butcher. 1986. J. Immunol. 136:3521.\n4. Reichert, R.A., I.L. Weissman, and E.C. Butcher. 1986. J. Immunol. 136:3529.\n5. Reichert, R.A., L. Jerabek, W.M. Gallatin, E.C. Butcher, and I.L. Weissman. 1986. J. Immunol. 136:3535.\n6. Iwabuchi, K., J. Ohgama, K. Ogasawara, C. Iwabuchi, I. Negishi, R.A. Good, and K. Onoe. 1991. Immunobiology 182:161.\n7. Lewinsohn, D.M., R.F. bargatze, and E.C. Butcher. 1987. J. Immunol. 138:4313.\n8. Pizcueta, P., and F.W. Luscinskas. 1994. Am. J. Pathol. 145:461.\n9. Ley, K., D.C. Bullard, M.L. Arbones, R. Bosse, D. Vestweber, T.F. Tedder, and A.L. Beaudet. 1995. J. Exp. Med. 181:669.\n10. Jung, T.M., W.M. Gallatin, I.L. Weissman, and M.O. Dailey. 1988. J. Immunol. 141:4110.\n11. Kishimoto, T.K., M.A. Jutila, E.L. berg, and E.C. Butcher. 1989. Science 245:1238.\n12. Mobley, J.L., and M.O. Dailey. 1992. J. Immunol. 148:2348.\n13. Sprent, J., and D.F. Tough. 1994. Science 265:1395.

Additional Info

Recognizes CD62L/L-selectin, Mr 90kD.