CD68 (Macrosialin, Gp110)

CD68 is a 110 kD glycoprotein, known as macrosialin, belongs to sialomucin family and is closely related to the family of acidic, highly glycosylated lysosomal-associated membrane proteins (lamps). CD68 is predominately expressed in cytoplasmic granules of monocytes/macrophages, dendritic cells, and granulocytes. It is one of the useful myeloid cell markers. Further studies have shown that CD68 is also expressed by a subset of hematopoietic progenitors, gamma/delta T cells, NK cells, LAK cells, subset of B cells, fibroblasts, and endothelial cells. The biological function of CD68 is still unknown.\n\nApplications:\nSuitable for use in Flow Cytometry and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

C2423-06F

Size

100ug

Applications

FC, IHC

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

P Type

Mab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG2b,k

References

1. Doussis, IA., et al. 1993. J. Clin. Pathol. 46:334. 2. Davey, FR., et al., 1988. J. Clin. Pathol. 41:753. 3. Holness, CL., and Simmons, D.L., 1993. Blood 81:1607. 4. Gottfried, E., et al. 2008. Scand. J. Immunol. 67:453. 5. Hameed, A., et al. 1994. Hum. Pathol. 25:872.

Additional Info

Recognizes human CD68.