CD74 (HLA-DR, DHLAG, HLA class II histocompatibility antigen gamma, HLADG, Ia antigen-associated invariant chain, Ia-Gamma, Ii, p33, protein 41 antigen invariant chain) (FITC)

CD74 represents a type II integral membrane protein known as MHC Class II-associated invariant chain (Mr 43, 41, 35, 33kD). It is moderately expressed on B cells, and weakly on monocytes and macrophages. CD74 is also found on a subset of activated T cells, Langerhans cells, dendritic cells and some epithelial cells. CD74 may play a role in antigen processing and presentation through intracellular transport and expression of Class II molecules on the cell surface.1-4\n\nApplications:\n

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SPECIFICATIONS

Catalog Number

C2430-01C1

Size

100Tests

Applications

FC, IHC, IP

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, 0.1% sodium azide and a stabilizing agent. Conjugated to FITC.

P Type

Mab

Purity

Purified

Isotype

IgG1

References

1. Knapp, W., B. Dorken, W.R. GIlks, E.P. Rieber, R.E. Schmidt, H. Stein, A.E.G.K. Von dem Borne, eds. 1989. Leukocyte Typing IV: White Cell Differentiation Antigens, Oxford University Press, Oxford.\n2. Barclay, A.N., M.H. Brown, S.K.A. Law, A.J. McKnight, M.G. Tomlinson, and P.A. van der Merwe, eds. 1997. The Leukocyte Antigens Facts Book, 2nd Edition, CD74 Section, Academic Press, New York, p. 327.\n3. Lamb, C.A., J.W. Yewdell, J.R. Bennink, and P. Cresswell. 1991. Proc. Natl. Acad. Sci. USA 88:5998.\n4. Viville, S., J. Neefjes, V. Lotteau, A. Dierich, M. Lemeur, H. Ploegh, C. Benoist, and D. Mathis. 1993. Cell 72:635.

Additional Info

Recognizes human CD74.

Alternative Names

CD74 antigen, DHLAG, HLA class II histocompatibility antigen gamma chain, HLADG, HLA-DR antigens-associated invariant chain, Ia antigen-associated invariant chain, Ia-GAMMA, Ii, p33, protein 41