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CD81 (TAPA-1, Target of anti-Proliferative Antibody-1) (FITC)

Cat no: C2433-21B

CD81 (TAPA-1, Target of anti-Proliferative Antibody-1) (FITC)

CD81 (Mr 25kD) is a member of the transmembrane 4 integral membrane protein family CD81/TAPA-1 is an integral membrane protein expressed on a variety of cell types, and has a high degree of sequence homology between human and mouse.1 CD81 is expressed on thymic stromal cells where it plays an important role in the transition of gamma/delta+ T cells to more mature T cells with alpha/beta T cell receptors.2 Immunohistochemical staining has revealed that its expression is localized to the subcapsular region of the thymus and, specifically, on cells that have distinct clustering patterns. It has been speculated that the ligand for CD81 is the pre-T cell receptor, which is composed of a TCR beta chain and glycoprotein pTalpha.2 This antibody can block thymocyte interaction with CD81 in vitro.2\n\nApplications\n

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SPECIFICATIONS

Catalog Number

C2433-21B

Size

500ug

Applications

FC, IHC, IP

Reactivities

Mouse

Form

Supplied as a liquid in PBS ,0.1% sodium azide. Conjugated to FITC.

P Type

Mab

Purity

Purified

Isotype

IgG3,k

References

1. Andria, M.L., et al. 1991. J. Immunol. 147:1030.\n2. Boismenu, R., M. Rhein, W.H. Fischer, and W.L. Harven. 1996. Science 271:198.

Additional Info

Recognizes mouse CD81 (Mr 25kD).

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