CD90 (Thy-1 Membrane Glycoprotein, Thy-1 Antigen, Thy1, Thy-1) (Azide Free)

CD90/Thy-1, a GPI-anchored molecule and one of the smallest members of the immunoglobulin superfamily of cell surface receptors, consists of a single V-set domain.1-4 It is expressed on thymocytes, peripheral T lymphocytes, some intraepithelial T lymphocytes and neurons of all mouse strains.1,2 This antibody stimulates T-cell proliferation and IL-2 secretion, via signalling through the T-cell receptor/CD3 complex.1,5-7 The antibody has also been reported to promote apoptosis of thymocytes and CTL clones,4,7 and to mediate adhesion of thymocytes to thymic stroma.8\n\nApplications:\n

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SPECIFICATIONS

Catalog Number

C2441-62AX

Size

500ug

Applications

FC, ICC

Hosts

Rat

Reactivities

Mouse

Form

Supplied as a liquid in PBS. No preservative added.

P Type

Mab

Purity

Purified

Isotype

IgG2c,k

References

1. Gunter, K., T. Malek, and E. Shevach. 1984. T-cell activating properties of an anti-Thy-1 monoclonal antibody. J. Exp. Med. 159:716. 2. Williams, A.F., and J. Gagnon. 1982. Science 216:696. 3. Kroczek, R.A., K.C. Gunter, R.N. Germain, and E.M. Shevach. 1986. Nature 322:181. 4. Hueber, A.O., G. Raposo, M. Pierres, and H.-T. He. 1994. J. Exp. Med. 179:785. 5. Tentori, L., D.M. Pardoll, J.C. Zunigaq, J. Hu-Li, W.E. Paul, J.A. Bluestone, and A.M. Kruisbeek. 1988. J. Immunol. 140:1089.\n6. Sugiyama, E., A. Cantagrei, T. Reno, F. Stafford-Brady, E.T.H. Yeh, and J.V. Bonventre. 1990. Cell. Immunol. 130:271. 7. Ucker, D.S., J. Meyers, and P.S. Obermuller. 1992. J. Immunol. 149:1583. 8. He, H.-T., P. Naquet, D. Caillol, and M. Pierres. 1991. J. Exp. Med. 173:515. 9. Kruisbeek, A.M., and E. Shevach. 1991. Proliferative assays for T cell function. In: Current Protocols in Immunology. Coligan, J., A. Kruisbeek, D. Margulies, E.M. Shevach, and W. Strober. John Wiley & Sons, New York, NY, pp. 3.12.1-3.12.14.

Additional Info

Recognizes Thy-1.1 and Thy-1.2 alloantigens (Thy-1 epitope region A).