CDK11A (Cyclin-dependent Kinase 11A, Cell Division Cycle 2-like Protein Kinase 2, Cell Division Protein Kinase 11A, Galactosyltransferase-associated Protein Kinase p58/GTA, PITSLRE Serine/Threonine-protein Kinase CDC2L2, CDC2L2, CDC2L3, PITSLREB)

Three major isoforms of Cdk11 identified are the full length gene product Cdk11p110 and the shorter polypeptides Cdk11p58 and Cdk11p46. Cdk11p110 is a component of RNA polymerase II containing complexes involved in transcriptional regulation, and is implicated in pre-mRNA splicing through interaction with the splicing factor RNPS1 (RNA-binding protein with serine-rich domain 1). Cdk11p58 has been linked with mitosis, cell cycle arrest and apoptosis, and recently implicated as a negative regulator of the androgen receptor (AR) as part of a cyclin D3/ Cdk11p58 complex. Cdk11p46 arises from the cleavage of Cdk11p110 and Cdk11p58 by caspases following the induction of apoptosis, and is linked with apoptotic progression.\n\nApplications:\nSuitable for use in Immunofluorescence and ELISA. Other applications not tested.\n\nRecommended Dilution:\nSandwich ELISA: The detection limit is ~0.03ng/ml\nImmunofluorescence: 10ug/ml\nOptimal dilutions to be determined by the researcher.\n\nAmino Acid Sequence:\nGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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