Home  >  Products  >  CIITA, CT (Class II Major Histocompatibility Complex Transactivator, Class II Trans Activator, C2TA, CIITA IV, MHC2TA, MHC Class II Transactivator, NLRA)
CIITA, CT (Class II Major Histocompatibility Complex Transactivator, Class II Trans Activator, C2TA, CIITA IV, MHC2TA, MHC Class II Transactivator, NLRA)

CIITA, CT (Class II Major Histocompatibility Complex Transactivator, Class II Trans Activator, C2TA, CIITA IV, MHC2TA, MHC Class II Transactivator, NLRA)

Cat no: C5072-61D

Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Read More on Supplier Website
CIITA regulates basal and interferon induced MHC-II transcription through interactions with multiple proteins including transcription factors, chromatin modifying enzymes and components of the basal transcription machinery. CIITA regulates MHC-II expression principally in immune cells, but can also affect their expression in endothelial and fibroblast cells. Mutations in this gene have been associated with bare lymphocyte syndrome type II, which leads to an extreme susceptibility to viral, bacterial and fungal infections. Silencing of CIITA through epigenetic mechanisms also has a major impact on MHC-II expression in tumor cells and can facilitate immune escape. Applications: Suitable for use in ELISA and Immunoprecipitation. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C5072-61D
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Immunoprecipitation
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.01% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Ion Exchange chromatography.
Alternative names: MHC Class II Transactivator Type III, NLR Family Acid Domain Containing, Nucleotide Binding Oligomerization Domain Leucine Rich Repeat and Acid Domain Containing
References: 1. Wright, K.L. and Ting, J.P. (2006) Epigenetic regulation of MHC-II and CIITA genes. Trends Immunol. 27: 405-412. 2. Zika, E. and Ting, J.P. (2005) 2. (2005). Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes. Curr. Opin. Immunol. 17: 58-64.
Additional info: Recognizes human Class II transactivator (CIITA).

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave