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Collagen Type XXV, alpha 1 (COL25A1, CLAC)

Collagen Type XXV, alpha 1 (COL25A1, CLAC)

Cat no: C7510-98H

Supplier: United States Biological
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Collagen XXV a1 (COL25A1), also known as CLAC-P and AMY, is an 80kD member of the transmembrane (TM) collagen family. It is type II TM hydroxylated glycoprotein that is expressed by neurons. Proteolytic cleavage generates 70kD monomers that either dimerizIgG2Be or trimerize, and bind to fibrillar amyloid b-peptide. Human COL25A1 is 654aa in length. It has a 600aa extracellular domain (aa55-654) that contains seven collagen-like regions and is cleaved by furin between Arg112 and Glu113. Multiple splice forms may exist. One shows a 5aa substitution for (aa441-654), while a second shows a 2aa substitution for (aa616-654). Three other isoforms show splicing over aa165-245 accompanied by complex splicing at the C-terminus. Over (aa189-654), human COL25A1 is 95% aa identical to mouse COL25A1. Applications: Suitable for use in ELISA and Immunohistochemistry. Other applications not tested. Recommended Dilution: Direct ELISA: 0.5-1ug/ml Immunohistochemistry (paraffin): 25ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Immunohistochemistry: Human Alzheimner
Catalogue number: C7510-98H
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Immunohistochemistry
Size: 100ug
Form: Supplied as a lyophilized powder in PBS, 5% trehalose. Reconstitute with sterile PBS.
P type: Mab
Isotype: IgG2b
Purity: Purified by Protein G affinity chromatography.
Additional info: Recognizes human COL25A1. Does not cross-react with recombinant, human COL1A1, 3A1, 4A1, 13A1, 23A1, or recombinant, mouse COL13A1.

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