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Collagen Type XXV, alpha 1 (COL25A1, CLAC)

Cat no: C7510-98H

Collagen Type XXV, alpha 1 (COL25A1, CLAC)

Collagen XXV a1 (COL25A1), also known as CLAC-P and AMY, is an 80kD member of the transmembrane (TM) collagen family. It is type II TM hydroxylated glycoprotein that is expressed by neurons. Proteolytic cleavage generates 70kD monomers that either dimerizIgG2Be or trimerize, and bind to fibrillar amyloid b-peptide. Human COL25A1 is 654aa in length. It has a 600aa extracellular domain (aa55-654) that contains seven collagen-like regions and is cleaved by furin between Arg112 and Glu113. Multiple splice forms may exist. One shows a 5aa substitution for (aa441-654), while a second shows a 2aa substitution for (aa616-654). Three other isoforms show splicing over aa165-245 accompanied by complex splicing at the C-terminus. Over (aa189-654), human COL25A1 is 95% aa identical to mouse COL25A1.\n\nApplications: \nSuitable for use in ELISA and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nDirect ELISA: 0.5-1ug/ml\nImmunohistochemistry (paraffin): 25ug/ml\nOptimal dilutions to be determined by the researcher.\n\nPositive Control: \nImmunohistochemistry: Human Alzheimner

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SPECIFICATIONS

Catalog Number

C7510-98H

Size

100ug

Applications

ELISA, IHC

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a lyophilized powder in PBS, 5% trehalose. Reconstitute with sterile PBS.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG2b

Additional Info

Recognizes human COL25A1. Does not cross-react with recombinant, human COL1A1, 3A1, 4A1, 13A1, 23A1, or recombinant, mouse COL13A1.

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SUPPLIER INFO

Applications

ELISA

Reactivities

Hum

More info

Applications

IF

Hosts

Mouse

More info

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, IHC, WB

Hosts

Mouse

More info

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info

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