Home  >  Products  >  DAND5(DAN domain family member 5, CER2, Cerberus-like protein 2, CERL2, Cerl-2, CKTSF1B3, COCO, CRL2, Cysteine knot superfamily 1, BMP antagonist 3, DAN domain family member 5, DANTE, DTE, FLJ38607, GREM3, Gremlin-3, MGC126849, SP1)
DAND5(DAN domain family member 5, CER2, Cerberus-like protein 2, CERL2, Cerl-2, CKTSF1B3, COCO, CRL2, Cysteine knot superfamily 1, BMP antagonist 3, DAN domain family member 5, DANTE, DTE, FLJ38607, GREM3, Gremlin-3, MGC126849, SP1)

DAND5(DAN domain family member 5, CER2, Cerberus-like protein 2, CERL2, Cerl-2, CKTSF1B3, COCO, CRL2, Cysteine knot superfamily 1, BMP antagonist 3, DAN domain family member 5, DANTE, DTE, FLJ38607, GREM3, Gremlin-3, MGC126849, SP1)

Cat no: D1038-08A

Supplier: United States Biological
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COCO, also known as DAND5, Dante, and CKTSF1B3, is a member of the DAN Domain family of BMP antagonists that includes DAN, Gremlin, PRDC, and Cerberus. COCO binds and inhibits Xnr1, BMP-4, Activin, and Wnt8. It is implicated in gastrulation and embryonic left-right axis formation. Human COCO shares 60% and 24% aa sequence identity with mouse and Xenopus COCO, respectively. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 2-8ug/ml Optimal dilutions to be determined by the researcher. Hybridoma: Mouse myeloma cells with B cells obtained from a mouse immunized with purified, E.coli- derived, recombinant human DAND5 (aa23-189). Storage and Stability: Lyophilized powder may be stored at -20 degrees C for short-term only. Reconstitute with sterile 40-50% glycerol, aliquot and store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: D1038-08A
Reactivities: Human
Hosts: Mouse
Applications: ELISA
Size: 500ug
Form: Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with sterile PBS.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
Additional info: Recognizes human DAND5. Does not crossreact or interfere with recombinant human Activan A, BMP-4, or DAN, nor recombinant mouse DAND5. Species Sequence Homology: mouse (60%), Xenopus (24%).

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