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DAND5(DAN domain family member 5, CER2, Cerberus-like protein 2, CERL2, Cerl-2, CKTSF1B3, COCO, CRL2, Cysteine knot superfamily 1, BMP antagonist 3, DAN domain family member 5, DANTE, DTE, FLJ38607, GREM3, Gremlin-3, MGC126849, SP1)

Cat no: D1038-08A

DAND5(DAN domain family member 5, CER2, Cerberus-like protein 2, CERL2, Cerl-2, CKTSF1B3, COCO, CRL2, Cysteine knot superfamily 1, BMP antagonist 3, DAN domain family member 5, DANTE, DTE, FLJ38607, GREM3, Gremlin-3, MGC126849, SP1)

COCO, also known as DAND5, Dante, and CKTSF1B3, is a member of the DAN Domain family of BMP antagonists that includes DAN, Gremlin, PRDC, and Cerberus. COCO binds and inhibits Xnr1, BMP-4, Activin, and Wnt8. It is implicated in gastrulation and embryonic left-right axis formation. Human COCO shares 60% and 24% aa sequence identity with mouse and Xenopus COCO, respectively.\n\nApplications: \nSuitable for use in ELISA. Other applications not tested.\n\nRecommended Dilution:\nELISA: 2-8ug/ml\nOptimal dilutions to be determined by the researcher.\n\nHybridoma: \nMouse myeloma cells with B cells obtained from a mouse immunized with purified, E.coli- derived, recombinant human DAND5 (aa23-189).\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C for short-term only. Reconstitute with sterile 40-50% glycerol, aliquot and store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

D1038-08A

Size

500ug

Applications

ELISA

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with sterile PBS.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG1

Additional Info

Recognizes human DAND5. Does not crossreact or interfere with recombinant human Activan A, BMP-4, or DAN, nor recombinant mouse DAND5. Species Sequence Homology: mouse (60%), Xenopus (24%).

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Applications

IHC

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

More info

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat, Dro/Arth

More info

Applications

IHC, IP, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat, Dro/Arth, NHP, Yeast/Fun

More info
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