Home  >  Products  >  DARC (NT) (Duffy blood group, chemokine receptor, CCBP1, CD234, CD234 antigen, Dfy, Duffy antigen/chemokine receptor, FY, Fy glycoprotein, Glycoprotein D, GPD, GpFy, Plasmodium vivax receptor)
DARC (NT) (Duffy blood group, chemokine receptor, CCBP1, CD234, CD234 antigen, Dfy, Duffy antigen/chemokine receptor, FY, Fy glycoprotein, Glycoprotein D, GPD, GpFy, Plasmodium vivax receptor)

DARC (NT) (Duffy blood group, chemokine receptor, CCBP1, CD234, CD234 antigen, Dfy, Duffy antigen/chemokine receptor, FY, Fy glycoprotein, Glycoprotein D, GPD, GpFy, Plasmodium vivax receptor)

Cat no: D1065-50E

Supplier: United States Biological
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DARC, also known as the Duffy antigen/chemokine receptor, is a seven-transmembrane protein homologous to the classical chemokine G-protein coupled receptors (GPCRs) with the exception of the motif required for G protein coupling (1). DARC can bind with high affinity several chemokines without transducing any signal, suggesting it may modulate the signals normally induced by these chemokines (2). Recently, DARC was found to interact with KAI1, a four transmembrane protein recently identified as a tumor metastasis suppressor protein (3). It is thought that tumor cells dislodged from the primary tumor and expressing KAI1 interact with DARC proteins expressed on vascular cells, transmitting a senescent signal to the tumor cells, while tumor cells that have lost KAI1 expression can proliferate and potentially give rise to metastases. At least three isoforms of DARC are known to exist. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1.0-2.0ug/ml Optimal dilutions to be determined by the researcher. Positive Control: PC-3 cell lysate. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: D1065-50E
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Chaudhuri A, et al (1993) Proc. Natl. Acad. Sci. USA. 90:10793-7. 2. Gardner L, et al (2004) Biochem. Biophys. Res. Commun. 321:306-12. 3. Gil ML, et al (1992) J. Immunol. 2826-33.
Additional info: Recognizes human DARC.

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