Home  >  Products  >  DcR3 (Tumor Necrosis Factor Receptor Superfamily Member 6B, Decoy Receptor 3, Decoy Receptor For Fas Ligand, M68, TNFRSF6B, TR6, UNQ186/PRO212)
DcR3 (Tumor Necrosis Factor Receptor Superfamily Member 6B, Decoy Receptor 3, Decoy Receptor For Fas Ligand, M68, TNFRSF6B, TR6, UNQ186/PRO212)

DcR3 (Tumor Necrosis Factor Receptor Superfamily Member 6B, Decoy Receptor 3, Decoy Receptor For Fas Ligand, M68, TNFRSF6B, TR6, UNQ186/PRO212)

Cat no: D1500-25H

Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Read More on Supplier Website
The DcR3 protein is a soluble member of the TNF receptor superfamily containing four TNF receptor domains with an approximate molecular weight of 35kD. DcR3, also known as Decoy receptor 3, TR6, M68, can be secreted by monocytes and myeloid-derived dendritic cells following exposure to bacterial antigens. DcR3 is overexpressed in tumors including lung and colon cancers, gliomas, and pancreatic cancers and can be detected in the serum of cancer patients. DcR3 can also be found in the cytoplasm and endoplasmic reticulum in some cell types. This protein competes for ligand binding with cell surface receptor and can inhibit their signaling. DcR3 has been shown to bind the ligands FasL, LIGHT, and TNF like molecule 1 (TL1A) to inhibit binding to the cell surface receptors Fas, HVEM and LT-BR, and death receptor 3 (DR3), respectively. Applications: Suitable for use in ELISA, Flow Cytometry, Western Blot, Immunohistochemistry and Immunoprecipitation. Other applications not tested. Recommended Dilution: Flow Cytometry: (same/less than)1ug/10e6 cells in 100ul Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D1500-25H
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Purified by affinity chromatography.
References: 1. Pitti, R. M., et al. 1998. Nature 396:699. 2. Bai, C., et al. 2000. Proc. Natl. Acad. Sci. USA 97:1230. 3. Yu, K.Y, et al. 1999. J. Biol. Chem. 274:13733. 4. Migone, T.S., et al. 2002. Immunity 16:479. 5. Hsu, T.-L., et al. 2005. J. Immunol. 175:5135.
Additional info: Recognizes human DcR3.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave