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DcR3 (Tumor Necrosis Factor Receptor Superfamily Member 6B, Decoy Receptor 3, Decoy Receptor For Fas Ligand, M68, TNFRSF6B, TR6, UNQ186/PRO212)

Cat no: D1500-25H

DcR3 (Tumor Necrosis Factor Receptor Superfamily Member 6B, Decoy Receptor 3, Decoy Receptor For Fas Ligand, M68, TNFRSF6B, TR6, UNQ186/PRO212)

The DcR3 protein is a soluble member of the TNF receptor superfamily containing four TNF receptor domains with an approximate molecular weight of 35kD. DcR3, also known as Decoy receptor 3, TR6, M68, can be secreted by monocytes and myeloid-derived dendritic cells following exposure to bacterial antigens. DcR3 is overexpressed in tumors including lung and colon cancers, gliomas, and pancreatic cancers and can be detected in the serum of cancer patients. DcR3 can also be found in the cytoplasm and endoplasmic reticulum in some cell types. This protein competes for ligand binding with cell surface receptor and can inhibit their signaling. DcR3 has been shown to bind the ligands FasL, LIGHT, and TNF like molecule 1 (TL1A) to inhibit binding to the cell surface receptors Fas, HVEM and LT-BR, and death receptor 3 (DR3), respectively.\n\nApplications:\nSuitable for use in ELISA, Flow Cytometry, Western Blot, Immunohistochemistry and Immunoprecipitation. Other applications not tested.\n\nRecommended Dilution:\nFlow Cytometry: (same/less than)1ug/10e6 cells in 100ul\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

D1500-25H

Size

100ug

Applications

ELISA, FC, IHC, IP, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

P Type

Mab

Purity

Purified by affinity chromatography.

Isotype

IgG1,k

References

1. Pitti, R. M., et al. 1998. Nature 396:699. 2. Bai, C., et al. 2000. Proc. Natl. Acad. Sci. USA 97:1230. 3. Yu, K.Y, et al. 1999. J. Biol. Chem. 274:13733. 4. Migone, T.S., et al. 2002. Immunity 16:479. 5. Hsu, T.-L., et al. 2005. J. Immunol. 175:5135.

Additional Info

Recognizes human DcR3.

Read more on Supplier website

Applications

IHC

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

More info

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat, Dro/Arth

More info

Applications

IHC, IP, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat, Dro/Arth, NHP, Yeast/Fun

More info
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