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Dicer (Endoribonuclease Dicer, Helicase with RNase Motif, Helicase MOI, DICER1, HERNA, KIAA0928)

Dicer (Endoribonuclease Dicer, Helicase with RNase Motif, Helicase MOI, DICER1, HERNA, KIAA0928)

Cat no: D3520-01K

Supplier: United States Biological
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Dicer is an RNase III-like enzyme which cleaves double-stranded RNA into 21-23 nt RNAs. These RNAs are referred to as siRNA (short interfering RNA). It is believed to be essential in siRNA-mediated gene suppression. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D3520-01K
Reactivities: Human
Hosts: Rabbit
Applications: ELISA
Size: 100ul
Form: Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Serum.
References: 1. Provost, P, et al. Dicer is required for chromosome segregation and gene silencing in fission yeast cells. Proc Natl Acad Sci USA. 2002 Dec 24;99(26):16648-53. Epub 2002 Dec 13. 2. Doi, N, et al. Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors. Curr Biol. 2003 Jan 8;13(1):41-6. 3. Zhang, H, et al. Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP. EMBO J. 2002 Nov 1; 21(21):5875-85.
Additional info: Recognizes human Dicer. Species sequence homology: mouse, rat, chimpanzee, canine, bovine, chicken

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