DPPX is a critical component of neuronal A-type K+ channels. DPPX encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. It has no detectable protease activity. DPPX bind specific voltage-gated potassium channels and alters their expression and biophysical properties. DPPX interacts with the voltage-gated potassium channel Kv4 and that co-expression of DPPX together with Kv4 pore forming alpha-subunits, and potassium channel interacting proteins (KChIPs), reconstitutes properties of native A-type potassium channels in vitro. Alternate transcriptional splice variants, encoding different isoforms, have been characterized, namely DPPX-S, DPPX-L, and DPPX-K. It localizes in the 7q36.2 region of chromosome. It is expressed predominantly in Human brain.
Applications:
Suitable for use in Immunohistochemistry. Other applications not tested.
Recommended Dilution:
Immunohistochemistry (paraffin): 20ug/ml
Optimal dilutions to be determined by the researcher.
Positive Control:
Brain, Neurons
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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