Home  >  Products  >  DNA polymerase delta interaction protein, p46 (POLDIP3, SKAR, polymerase (DNA-directed), delta interacting protein 3, 46kD DNA polymerase delta interaction protein, KIAA1649, p46, PDIP46, Polymerase delta-interacting protein 3)
DNA polymerase delta interaction protein, p46 (POLDIP3, SKAR, polymerase (DNA-directed), delta interacting protein 3, 46kD DNA polymerase delta interaction protein, KIAA1649, p46, PDIP46, Polymerase delta-interacting protein 3)

DNA polymerase delta interaction protein, p46 (POLDIP3, SKAR, polymerase (DNA-directed), delta interacting protein 3, 46kD DNA polymerase delta interaction protein, KIAA1649, p46, PDIP46, Polymerase delta-interacting protein 3)

Cat no: D3935-23D

Supplier: United States Biological
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The mammalian target of rapamycin (mTOR) and phosphatidylinositol 3-kinase (PI3K) signaling pathways promote cell growth and cell cycle progression in response to nutritional, energy, and mitogenic cues. In mammalian cells, the ribosomal protein S6 kinases, S6K1 and S6K2, lie downstream of mTOR and PI3K, suggesting that translational control through the phosphorylation of S6 regulates cell growth. SKAR is a specific binding partner and substrate of S6K1 but not S6K2. Serines 383 and 385 of human SKAR are insulin-stimulated and rapamycin-sensitive S6K1 phosphorylation sites. SKAR is nuclear protein with homology to the Aly/REF family of RNA binding proteins, which has been proposed to couple transcription with pre-mRNA splicing and mRNA export. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Positive Control: HeLa cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: D3935-23D
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid, 0.09% sodium azide.
P type: Pab
Purity: Serum
References: 1. Richardson, C.J., et al. (2004). Curr Biol. 7,14(17):1540-9.
Additional info: Recognizes human SKAR. Species Crossreactivity: mouse, rat.

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