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DNER (Delta and Notch-like Epidermal Growth Factor-related Receptor, Brain EGF Repeat Containing Transmembrane Protein, BET)

DNER (Delta and Notch-like Epidermal Growth Factor-related Receptor, Brain EGF Repeat Containing Transmembrane Protein, BET)

Cat no: D4016-85B

Supplier: United States Biological
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DNER, a neuron specific EGF-like repeat containing transmembrane protein, acts as a functional ligand of Notch and regulates morphologic differentiation of glia in the vertebrate brain. Like other Notch ligands, DNER specifically binds to Notch1 expressing cells and induces intracellular cleavage of Notch1 at the S3 site, thus mediating the Notch signaling pathway. The protein exerts a regulatory role in dendritic patterning of the central nervous system neurons. The human DNER gene is localized on chromosome 2q37. The protein is strongly expressed in several types of postmitotic neurons including cortical and hippocampal pyramidal neurons, cerebellar granule cells and Purkinje cells. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D4016-85B
Reactivities: Human, Mouse, Canine
Hosts: Rabbit
Applications: ELISA
Size: 100ul
Form: Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Serum
References: 1. Eiraku, M. et al. J. Biol. Chem. 277:25400-25407 (2002). 2. Nishizumi, H. et al. Neuroreport. 13:909-915 (2002).
Additional info: Recognizes human DNER. Species Crossreactivity: chimpanzee, canine, mouse. Species sequence homology: chicken.

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