Home  >  Products  >  Dock2 (Dedicator of Cytokinesis 2, AI662014, AW122239, CED-5, Dedicator of Cytokinesis Protein 2, Hch, MBC, Protein Hch)
Dock2 (Dedicator of Cytokinesis 2, AI662014, AW122239, CED-5, Dedicator of Cytokinesis Protein 2, Hch, MBC, Protein Hch)

Dock2 (Dedicator of Cytokinesis 2, AI662014, AW122239, CED-5, Dedicator of Cytokinesis Protein 2, Hch, MBC, Protein Hch)

Cat no: D8080-20B

Supplier: United States Biological
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Dock2 (Dedicator of cytokinesis 2), is a large protein involved in intracellular signaling networks and a member of the DOCK-A subfamily which function as activators of small G proteins. Dock2 specifically activates isoforms of the small G protein Rac and appears to be expressed specifically in leukocytes. These cells express both Rac1 and Rac2 and Dock2 has been shown to bind and promote nucleotide exchange on both of these isoforms. (Nishihara, 1999) Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5mg/ml Optimal dilutions to be determined by the researcher. Positive Control: Mouse spleen lysate Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: D8080-20B
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Gotoh K., et al. (2008). Blood. 111(6):2973-76. 2. Nombela-Arrieta C., et al. (2007). J. Exp. Med. 204(3):497-510. 3. Nishihara H., et al. (1999). Biochem. Biophys. Acta. 1452(2):179-87.
Additional info: Recognizes mouse DOCK2. Species sequence homology: human, horse, primates (93%). The sequence is 85.7% homologous in rat.

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