Home  >  Products  >  DOK5 (Docking Protein 5, Downstream Of Tyrosine Kinase 5, Insulin Receptor Substrate 6, IRS-6, IRS6, C20orf180)
DOK5 (Docking Protein 5, Downstream Of Tyrosine Kinase 5, Insulin Receptor Substrate 6, IRS-6, IRS6, C20orf180)

DOK5 (Docking Protein 5, Downstream Of Tyrosine Kinase 5, Insulin Receptor Substrate 6, IRS-6, IRS6, C20orf180)

Cat no: D8080-05D

Supplier: United States Biological
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DOK5 represent a new signaling protein which has a potential role in insulin and IGF-1 action. This is an adapter proteins involved in signal transduction. DOK5 genes expressed in T cells and its expression is highest in skeletal muscle. This protein is tyrosine-phosphorylated in response to insulin and IGF-1 in transfected cells, It neither associates with these Src homology 2 domains nor activates MAPK. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.1ug/ml Immunohistochemistry (paraffin): 1ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human Kidney lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D8080-05D
Reactivities: Human
Hosts: Goat
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Cai D, Dhe-Paganon S, Melendez PA, Lee J, Shoelson SE. Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5. J Biol Chem. 2003 Jul 11;278(28):25323-30. Epub 2003 May 01. PMID: 12730241.
Additional info: Recognizes human DOK5. Species sequence homology: mouse and rat.

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