ER(beta) (E101) pAb

Cat no: BS2429

Supplier: Bioworld Technology, Inc.

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The discovery of a second estrogen receptor has redefined the estrogen signaling pathway and may have broad implications on estrogen-responsive tissues.1 The new estrogen receptor, named estrogen receptor-beta (ER(beta)), is preferentially expressed in the prostate and maintains some characteristics that are different from ER(alpha).2 The rat tissue distribution and/or the relative level of ER(alpha) and ER(beta) expression seems to be quite different, i.e., moderate to high expression in uterus, testis, pituitary, ovary, kidney, epididymis, and adrenal for ER(alpha) and prostate, ovary, lung, bladder, brain, bone, uterus, and testis for ER(beta). Within the same organ it often appears that the ER subtypes are expressed in different cell types, supporting the hypothesis that the ER's may have different biological functions. The discovery of ER(beta) suggests the existence of two previously unrecognized pathways of estrogen signaling, via the ER(beta) subtype in tissues exclusively expressing this subtype and via the formation of heterodimers in tissues expressing both ER subtypes.The existence of two ER subtypes, their differential expression pattern, and different actions on certain response elements could provide explanations for the striking species-, cell-, and promoter-specific actions of estrogens and antiestrogens.3 Both estrogen receptors appear to be involved in a multitude of regulatory events.

Catalogue number:	BS2429
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Immunofluorescence, Western Blot
Size:	100ug/100ul
Swiss prot:	Q92731
Dilutions:	WB: 1:500~1:1000 IF: 1:50~1:200
Form:	liquid
Storage buffer:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration:	1ug/ul
Antigen:	Synthetic peptide, corresponding to amino acids 71-120 of Human ER(beta).
Species:	ER-(beta) (E101) pAb detects endogenous levels of ER-(beta) protein.
Molecular weight:	~ 48, 60 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp:	Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names:	ESR2; ER-BETA; ERB; ESR-BETA; ESRB; ESTRB; NR3A2
Additional info:	For research use only, not for use in diagnostic procedure.

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ER(beta) (E101) pAb

Cat no: BS2429

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