ER(beta) (E101) pAb

The discovery of a second estrogen receptor has redefined the estrogen signaling pathway and may have broad implications on estrogen-responsive tissues.1 The new estrogen receptor, named estrogen receptor-beta (ER(beta)), is preferentially expressed in the prostate and maintains some characteristics that are different from ER(alpha).2 The rat tissue distribution and/or the relative level of ER(alpha) and ER(beta) expression seems to be quite different, i.e., moderate to high expression in uterus, testis, pituitary, ovary, kidney, epididymis, and adrenal for ER(alpha) and prostate, ovary, lung, bladder, brain, bone, uterus, and testis for ER(beta). Within the same organ it often appears that the ER subtypes are expressed in different cell types, supporting the hypothesis that the ER's may have different biological functions. The discovery of ER(beta) suggests the existence of two previously unrecognized pathways of estrogen signaling, via the ER(beta) subtype in tissues exclusively expressing this subtype and via the formation of heterodimers in tissues expressing both ER subtypes.The existence of two ER subtypes, their differential expression pattern, and different actions on certain response elements could provide explanations for the striking species-, cell-, and promoter-specific actions of estrogens and antiestrogens.3 Both estrogen receptors appear to be involved in a multitude of regulatory events.

Prices direct from Bioworld Technology, Inc.

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

BS2429

Size

100ug/100ul

Applications

IF, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 71-120 of Human ER(beta).

Species

ER-(beta) (E101) pAb detects endogenous levels of ER-(beta) protein.

Dilutions

WB: 1:500~1:1000\nIF: 1:50~1:200

Swiss Prot

Q92731

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul