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FOXP3 (Forkhead Box P3, AIID, DIETER, IPEX, JM2, PIDX, SCURFIN, XPID)

Cat no: F9050-10F

FOXP3 (Forkhead Box P3, AIID, DIETER, IPEX, JM2, PIDX, SCURFIN, XPID)

FOXP3 is a member of the forkhead/winged-helix family of transcriptional regulators and is highly conserved across mammals. FOXP3 is essential for normal immune homeostasis. \nFOXP3 is stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene and a more specific marker of regulatory T cells than other T cells.\n\nApplications: \nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

F9050-10F

Size

100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum

Form

As reported

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

References

1. Polanczyk MJ, et al. Cutting edge: estrogen drives expansion of the CD4+CD25+ regulatory T cell compartment. J Immunol. 173(4:2227-30 (2004)\n2. Ochs, HD, et al. FOXP3 acts as a rheostat of the immune response. Immunol Rev. 203:156-64 (2005)

Additional Info

Specific for murine FOXP3. Species Crossreactivity: It does react with human protein but very weakly. Other species have not been tested.

Alternative Names

MGC141961, MGC141963

Read more on Supplier website

Applications

IHC

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

More info

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat, Dro/Arth

More info

Applications

IHC, IP, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat, Dro/Arth, NHP, Yeast/Fun

More info
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