Home  >  Products  >  FPR1 (fMet-Leu-Phe Receptor, fMLP Receptor, N-formyl Peptide Receptor, FPR, N-formylpeptide Chemoattractant Receptor)
FPR1 (fMet-Leu-Phe Receptor, fMLP Receptor, N-formyl Peptide Receptor, FPR, N-formylpeptide Chemoattractant Receptor)

FPR1 (fMet-Leu-Phe Receptor, fMLP Receptor, N-formyl Peptide Receptor, FPR, N-formylpeptide Chemoattractant Receptor)

Cat no: F6010-05A

Supplier: United States Biological
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FPR1 is a member of chemoattractant:chemokine GPCRs expressed mainly on leukocytes, neutrophils and monocytes. FPR1 is a seven transmembrane pertussis toxin-sensitive GPCR and binds to formylated peptides generated by bacteria resulting in leukocyte trafficking to the site of inflammation. Ligand binding to FPR results in activation of multiple effectors including phospholipase C leading to calcium mobilization and PKC activation. Other implications of FPR signaling include polarization of actin cytoskeletion, activation of various integrins, increased cell migration, phagocytosis, degranulation and release of reactive oxygen intermediates. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-3ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Liver lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: F6010-05A
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Gripentrog,J.M. and Miettinen,H.M. Activation and nuclear translocation of ERK1/2 by the formyl peptide receptor is regulated by G protein and is not dependent on beta-arrestin translocation or receptor endocytosis. Cell. Signal. 17 (10), 1300-1311 (2005) 2. Paruch,S., El-Benna,J., Djerdjouri,B., Marullo,S. and Perianin,A. A role of p44/42 mitogen-activated protein kinases in formyl-peptide receptor-mediated phospholipase D activity and oxidant production. FASEB J. 20 (1), 142-144 (2006) 3. Zhou,Y., Bian,X., Le,Y., Gong,W., Hu,J., Zhang,X., Wang,L., Iribarren,P., Salcedo,R., Howard,O.M., Farrar,W. and Wang,J.M. Formylpeptide receptor FPR and the rapid growth of malignant human gliomas. J. Natl. Cancer Inst. 97 (11), 823-835 (2005).
Additional info: Recognizes human FPR1. Species Crossreactivity: chimpanzee, gorilla, orangutan.

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