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GCSc-(gamma) (E315) pAb

GCSc-(gamma) (E315) pAb

Cat no: BS2926

Supplier: Bioworld Technology, Inc.
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The GCLC gene consists of 16 exons and encodes the 636 amino acid protein (gamma)-GCSc ((gamma)-glutamylcysteine synthetase heavy subunit), also designated (gamma)-Lglutamate- L-cysteine ligase catalytic subunit (GLCLC). (gamma)-GCSc is expressed in hemocytes, brain, liver and kidney. (gamma)-GCSc associates with a regulatory or modifier subunit, (gamma)-GCSm ((gamma)-glutamylcysteine synthetase light subunit), to form a heterodimer, (gamma)-GCS. (gamma)-GCS is the first enzyme involved and the rate determining step in glutathione iosynthesis. Oxidants, cadium and methyl mercury upregulate the transcription of (gamma)-GCS. H2O2 regulation depends on the Yap1 protein and the presence of glutamate, glutamine and lysine. Cadium regulates transcription through proteins Met-4, Met-31 and Met-32. Cbf1, a DNA binding protein, inhibits transcription of (gamma)-GCS.
Catalogue number: BS2926
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: P48506
Dilutions: WB: 1:500~1:1000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 300-350 of Human GCSc-(gamma).
Species: GCSc-(gamma) (E315) pAb detects endogenous levels of GCSc-(gamma) protein.
Molecular weight: ~ 70 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Glutamate--cysteine ligase catalytic subunit; 6.3.2.2; GCS heavy chain; Gamma-ECS Gamma-glutamylcysteine synthetase; GLCL; GLCLC; GCLC
Additional info: For research use only, not for use in diagnostic procedure.

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