GCSc-gamma (E315) Peptide

Cat no: BS2926P

Supplier: Bioworld Technology, Inc.

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Description
Additional Information

The GCLC gene consists of 16 exons and encodes the 636 amino acid protein gamma -GCSc (gamma -glutamylcysteine synthetase heavy subunit), also designated gamma -Lglutamate- L-cysteine ligase catalytic subunit (GLCLC). gamma -GCSc is expressed in hemocytes, brain, liver and kidney. gamma -GCSc associates with a regulatory or modifier subunit, gamma -GCSm (gamma -glutamylcysteine synthetase light subunit), to form a heterodimer, gamma -GCS. gamma -GCS is the first enzyme involved and the rate determining step in glutathione iosynthesis. Oxidants, cadium and methyl mercury upregulate the transcription of gamma -GCS. H2O2 regulation depends on the Yap1 protein and the presence of glutamate, glutamine and lysine. Cadium regulates transcription through proteins Met-4, Met-31 and Met-32. Cbf1, a DNA binding protein, inhibits transcription of gamma -GCS.

Catalogue number:	BS2926P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	P48506
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide GCSc-gamma (E315). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	Glutamate--cysteine ligase catalytic subunit; 6.3.2.2; GCS heavy chain; Gamma-ECS Gamma-glutamylcysteine synthetase; GLCL; GLCLC; GCLC
Additional info:	This peptide can be used with studies using BS2926 GCSc-gamma (E315) pAb.

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GCSc-gamma (E315) Peptide

Cat no: BS2926P

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