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GFRalpha-4 (P178) Peptide

Cat no: BS3304P

GFRalpha-4 (P178) Peptide

Glial cell line-derived neurotrophic factor (GDNF) and the related neurotrophic factor neurturin (NTN) are potent survival factors for central and peripheral neurons. Receptors for these factors include GFRalpha-1 (previously designated GDNFR-alpha), GFRalpha-2 (also designated RETL2), GFRalpha-3 and GFRalpha-4 (also known as persephin receptor). The receptors do not contain transmembrane domains and are attached to the cell membrane by glycosylphosphoinositol linkage. Binding of GDNF or NTN to one of these receptors leads to the activation of the tyrosine kinase Ret. GFRalpha-4 mediates the activation and GDNF-induced autophosphorylation of the RET receptor. It is mainly expressed in the adult thyroid gland, but lower levels may also be detected in fetal adrenal and thyroid glands.

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SPECIFICATIONS

Catalog Number

BS3304P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide GFRalpha-4 (P178). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

Q9GZZ7

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS3304 GFRalpha-4 (P178) pAb.

Alternative Names

GDNF family receptor alpha-4; GDNF receptor alpha-4; GDNFR-alpha-4; GFR-alpha-4; Persephin receptor; GFRA4\n

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