Ghrelin is a peptide hormone known in mammals to, among other effects, stimulate gut motility. It is a ligand for the growth hormone secretagogue receptor (GHS-R), a G protein-coupled receptor that is acted upon by small synthetic molecules known as growth hormone secretagogues (GHS). The action of the GHS upon the GHS-R stimulates the release of growth hormone from the pituitary. Thus, growth hormone release from the pituitary is governed by both hypothalamic GH-releasing hormone and ghrelin derived from the stomach. The third aa in ghrelin, usually a serine but sometimes a threonine, is modified by a fatty acid to activate the hormone. Ghrelin functions to stimulate appetite by activating the hypothalamic arcuate nucleus, a region of the brain known to control food intake. Ghrelin is also present in the bloodstream during fasting conditions, suggesting an additional role in hunger signal regulation. Ghrelin fish paralogues have been documented in zebrafish and three species of pufferfish, suggesting possible roles as models in the study of ghrelin.
Applications:
Suitable for use in ELISA. Other applications not tested.
Recommended Dilution:
ELISA: 1:5000-1:20,000
Optimal dilutions to be determined by the researcher.
Control Peptide: G2033-78P
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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