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HCN2 (E521) pAb

Cat no: BS3372

HCN2 (E521) pAb

Hyperpolarization-activated, cyclic nucleotide-binding channels (HCN) are voltage-gated cation channels that are activated by direct binding of intracellular cyclic nucleotides. The HCN family consists of four members (HCN1-4), each with a core transmembrane segment domain and a carboxy-terminal 120 amino-acid cyclic nucleotide-binding domain motif. HCN channels are expressed in the brain, heart, thalamus and testis. The pacemaker properties of HCN channels contribute to spontaneous rhythmic activity in the brain and heart. The genes encoding human HCN1 and HCN2 map to chromosomes 5 and 19p13.3, respectively. The genes encoding HCN3 and HCN4 map to chromosomes 1q21.3 and 15q24-q25, respectively.

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SPECIFICATIONS

Catalog Number

BS3372

Size

100ug/100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 490-541 of Human HCN2.

Species

HCN2 (E521) pAb detects endogenous levels of HCN2 protein.

Dilutions

WB: 1:500~1:1000

Swiss Prot

Q9UL51

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 100 kDa

Alternative Names

HCN2; BCNG-2; BCNG2; HAC-1

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