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HMG20A (High Mobility Group Protein 20A, HMG Box-containing Protein 20A, HMG Domain-containing Protein 1, HMG Domain-containing Protein HMGX1, HMGX1, HMGXB1)

Cat no: H6206-40D

HMG20A (High Mobility Group Protein 20A, HMG Box-containing Protein 20A, HMG Domain-containing Protein 1, HMG Domain-containing Protein HMGX1, HMGX1, HMGXB1)

Plays a role in neuronal differentiation as chromatin-associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase MLL and consequent increased methylation of histone H3 lysine 4.\n\nApplications:\nSuitable for use in ELISA and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:32,000 \nImmunohistochemistry (Paraffin): 1-2ug/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

H6206-40D

Size

100ug

Applications

ELISA, IHC

Hosts

Goat

Reactivities

Hum, Mouse, Rat, Bov, Can, Prc

Form

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

References

1. Artegiani B, Labbaye C, Sferra A, Quaranta MT, Torreri P, Macchia G, Ceccarini M, Petrucci TC, Macioce P. The interaction with HMG20a/b proteins suggests a potential role for beta-dystrobrevin in neuronal differentiation. J Biol Chem. 2010 Aug 6;285(32):24740-50.

Additional Info

Recognizes human HMG20A. Species Crossreactivity: Rat. Species sequence homology: Bovine, canine, mouse and porcine.

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