Home  >  Products  >  HSD3B1 (3 beta-hydroxysteroid Dehydrogenase/Delta 5->4-isomerase Type 1, 3 beta-hydroxysteroid Dehydrogenase/Delta 5->4-isomerase Type I, 3-beta-HSD I, Trophoblast Antigen FDO161G, 3BH, HSDB3A)
HSD3B1 (3 beta-hydroxysteroid Dehydrogenase/Delta 5->4-isomerase Type 1, 3 beta-hydroxysteroid Dehydrogenase/Delta 5->4-isomerase Type I, 3-beta-HSD I, Trophoblast Antigen FDO161G, 3BH, HSDB3A)

HSD3B1 (3 beta-hydroxysteroid Dehydrogenase/Delta 5->4-isomerase Type 1, 3 beta-hydroxysteroid Dehydrogenase/Delta 5->4-isomerase Type I, 3-beta-HSD I, Trophoblast Antigen FDO161G, 3BH, HSDB3A)

Cat no: 128104

Supplier: United States Biological
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3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Efficiently catalyzes the transformation of pregnenolone to progesterone, 17-alpha-hydroxypregnenolone to 17-alpha-hydroxyprogesterone, DHEA to 4-androstenedione, dihydrotestosterone to 5-alpha-androstane-3 beta,17 beta-diol, dehydroepiandrosterone to androstenedione and 5-alpha-androstan-3 beta,17 beta-diol to 5-alpha-dihydrotestosterone. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 3ug/ml Optimal dilutions to be determined by the researcher. AA Sequence: MTGWSCLVTGAGGFLGQRIIRLLVKEKELKEIRVLDKAFGPELREEFSKLQNKTKLTVLEGDILDEPFLKRACQDVSVIIHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVPVFIYTSSIEVAGPNSYKEIIQNGHEEEPLENTWPAPYPHSKKLAEKAVLAANGWNLKNGGTLYTCALRPMYIYGEGSRFLSASINEALNNNGILSSVGKFSTVNPVYVGNVAWAHILALRALQDPKKAPSIRGQFYYISDDTPHQSYDNLNYTLSKEFGLRLDSRWSFPLSLMYWIGFLLEIVSFLLRPIYTYRPPFNRHIVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAKQKTVEWVGSLVDRHKENLKSKTQ Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: 128104
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2.
P type: Mab
Isotype: IgG1,k
Purity: Purified by Protein A affinity chromatography.
References: 1. Gestational Trophoblastic Tumors and Related Tumor-Like Lesions. Shih IM, Mazur MT, Kurman RJ.Blaustein's Pathology of the Female Genital Tract 2011, 1075-1135, DOI: 10.1007/978 -1-4419-0489-8_20 2. Advances in the diagnosis of gestational trophoblastic tumors and tumor-like lesions. Mao TL, Shih IM.Expert Opin. Med. Diagn. (2009) 3(4):371-380. 3. Chorangiocarcinoma: A Case Report and Review of the Literature. Ariel I, Boldes R, Weintraub A, Reinus C, Beller U, Arbel R.Int J Gynecol Pathol. 2009 May;28(3):267-71. 4. HSD3B1 as a novel trophoblast-associated marker that assists in the differential diagnosis of trophoblastic tumors and tumorlike lesions. Mao TL, Kurman RJ, Jeng YM, Huang W, Shih IM.Am J Surg Pathol. 2008 Feb;32(2):236-42. 5. Trophogram, an immunohistochemistry-based algorithmic approach, in the differential diagnosis of trophoblastic tumors and tumorlike lesions. Shih IeM.Ann Diagn Pathol. 2007 Jun;11(3):228-34.
Additional info: Recognizes human HSD3B1.

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