Interleukin-23 (IL-23) is a heterodimeric cytokine and a member of the IL-12 family involved in innate and adaptive immunity. It is composed of the IL-12 p40 chain covalently linked to p19, a chain related to the IL-12 p35 subunit. IL-23 signals through the IL-23 receptor complex, which is composed of the IL-12Rbeta1 chain and a gp130-like chain, IL-23R. Triggering of the IL-23 receptor complex leads to the activation of Tyk2, Jak2 and STAT1, 3 and 4. IL-23 induces IFN-gamma production, Th1 cell differentiation, and activation of the antigen-presenting functions of dendritic cells. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and important for tumorigenesis.
Biological Activity:
Induction of IL-17 secretion by mouse splenocytes.
Sequence:
Human IL-23 p40 peptide (aa 23-328) is fused at the C-terminus to a 18 aa linker peptide (GSTSGSGKPGSGEGSTKG) and to the p19 peptide (aa 20-189) and fused at the N-terminus to a FLAG(R)-tag.
Storage and Stability:
Short-term Storage: +4 degrees C
Long-term Storage: -20 degrees C
Working aliquots are stable for up to 3 months when stored at -20 degrees C.
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