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Integrin, beta8

Cat no: I7661-46B

Integrin, beta8

Integrin beta 8 (Integrin b8) is a 90kD type I transmembrane glycoprotein of the Integrin family of adhesion molecules. It associates with Integrin aV to form a receptor for vitronectin, fibrin, and the latency associated peptide (LAP). Binding to LAP promotes the proteolytic release of active TGF-b from LAP. Integrin aVb8 is required for vascular morphogenesis in the embryonic brain and yolk sac. Within the extracellular domain, human Integrin b8 shares 87% aa sequence identity with mouse and rat Integrin b8.\n\nApplications: \nSuitable for use in Flow Cytometry and Direct ELISA. Other applications not tested.\n\nRecommended Dilutions:\nFlow Cytometry: 2.5ug labels 1x10e6 A172 human glioblastoma cells.\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

I7661-46B

Size

100ug

Applications

ELISA, FC

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a lyophilized powder from PBS, pH 7.4, 5% trehalose. Reconstitute with 200ul sterile PBS.

P Type

Mab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG2b

Additional Info

Recognizes human Integrin b8. Does not react with recombinant human Integrins b1, b2, b3, b4, b5, b6, or b7 or recombinant mouse Integrin b8.

Read more on Supplier website

Applications

ELISA

Reactivities

Hum

More info

Applications

IF

Hosts

Mouse

More info

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, IHC, WB

Hosts

Mouse

More info

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info

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